Everywhere around us, there are signs of a psychedelic renaissance: in medicine, therapy, commerce, and the arts.

These drugs are getting serious, positive coverage in glossy magazines, best-selling books, literary memoirs, documentaries, and hit podcasts. Performers like Reggie Watts, Melissa Etheridge, and members of the Flaming Lips openly acknowledge the role of hallucinogens in their work. And a flourishing psychedelic comedy scene is springing out all over the place.

But federal prohibition of psychedelics—a term that refers to a broad category of consciousness- and perception-altering substances—is also changing. The Food and Drug Administration (FDA) is expected to approve therapy using psilocybin, the psychoactive ingredients in magic mushrooms, and MDMA, the drug also known as ecstasy and molly. And Oregon and Colorado have decriminalized the recreational use of plant-based psychedelics.

Are psychedelics transcending their countercultural associations and moving squarely into the mainstream of science, medicine, wellness, and personal growth? In the new documentary, The Psychedelic Renaissance Is Here, Reason’s Nick Gillespie and Zach Weissmueller investigate this new, exciting cultural phenomenon.