As the months roll by, the pandemic continues to hit Indigenous nations hard. But this phenomenon is not new. Epidemics have been part of colonialism since settlers arrived. Health inequities tell us that illnesses have different outcomes on different populations; however, leading medical professionals warn the general public of the dangers of oversimplifying health data. They don’t tell the whole story. And, in the case of Indigenous nations, the story of inequity is imbued with dispossession of lands and is met with organizing from the inside: two crucial points for untangling and responding to COVID-19.